Plasma Amino Acids in NAFLD Patients with Obesity Are Associated with Steatosis and Fibrosis: Results from the MAST4HEALTH Study

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been linked to changes in amino acid (AA) levels. The objective of the current study was examine relationship between MRI parameters that reflect inflammation fibrosis plasma AA concentrations NAFLD patients. Plasma levels 97 patients from MAST4HEALTH were quantified with liquid chromatography. Medical, anthropometric lifestyle characteristics collected biochemical parameters, as well inflammatory oxidative stress biomarkers, measured. In total, subjects a higher MRI-proton density fat fraction (MRI-PDFF) exhibited compared lower PDFF. BCAAs (p-Value: 0.03), AAAs 0.039), L-valine 0.029), L-tyrosine 0.039) L-isoleucine 0.032) found be significantly PDFF group group. varied according MRI-PDFF. Significant associations also demonstrated AAs MRI-PDFF MRI-cT1, showing potential utility circulating diagnostic markers NAFLD.